So I have returned to the United States and back on assignment for the next couple of months, so it’s time to get down to business.
A couple of new HIPEC articles came out – which I thought readers might enjoy. For lighter fare, we will start with an article from the Vancouver Sun.
The first article, by Erin Ellis of the Vancouver Sun, is a Canadian fluff piece complete with sensationalistic headlines and dramatic patient interviews designed to draw attention to Vancouver General Hospital’s new HIPEC program.
Dr. Fernando Arias, Chief of the HIPEC program at Santa Fe de Bogotá
Now for the meat and potatoes
The second article, which is more academically and scientifically based, is focused on a study presented at the Southern Surgical Association in December by Levine, et. al. (2014) “Intraperitoneal Chemotherapy for Peritoneal Surface Malignancy: Experience with 1,000 Patients” looks at long-term survival with HIPEC in patients with disseminated peritoneal malignancies. This study is remarkable for both the duration of the prospective study (which began in 1991) and the large amount of participants for a single site study. The vast majority of patients enrolled in this study had appendiceal cancer as their primary, but the study also included patients with ovarian, gastric, mesothelioma and colorectal cancers.
The evolution of the procedure and institutional experience led to improved outcomes and reduced complications over the course of the study. Part of this was due to the development of better patient selection criteria.
This information comes as a ray of hope for patients with these diagnoses and previously given only dismal prognoses.
Dr. Edward Levine, the primary investigator, is the Chief of Surgical Oncology and Director of the Comprehensive Cancer Center at Wake Forest Medical Center in North Carolina.
It was published in the Journal of the American College of Surgeons, and summarized here, at Heme/Onc Today
Levine, et. al. (2014). Intraperitoneal Chemotherapy for Peritoneal Surface Malignancy: Experience with 1,000 Patients. Journal of the American College of Surgeons, 218(4): 573–585 (April 2014). No free text available.
Additional HIPEC posts: the HIPEC archives